摘要
目的了解医院临床标本中分离的嗜麦芽寡养单胞菌检出规律、分布状况及耐药特点。方法回顾分析医院2008年10月-2009年9月住院患者各种送检标本中分离的349株嗜麦芽寡养单胞菌,计算其构成比、科室分离率,并统计分析与嗜麦芽寡养单胞菌同时检出的微生物,分析嗜麦芽寡养单胞菌的药敏结果。结果呼吸内科、综合ICU、神经外科和血液内科等科室分离出的嗜麦芽寡养单胞菌占全院检出率的56.4%;主要标本来源为痰液和支气管灌洗液,占总数的95.4%;绝大部分为混合感染或多重感染,70.5%的嗜麦芽寡养单胞菌感染患者同时感染了其他细菌或真菌等病原菌;磺胺甲噁唑/甲氧苄啶、头孢哌酮/舒巴坦、米诺环素和左氧氟沙星的敏感率较高,均>75.0%,可用于临床经验治疗。结论嗜麦芽寡养单胞菌引起的感染因其耐药性高而应引起临床医师的高度关注;及时送检标本进行微生物学检测并根据药敏结果选择抗菌药物才能有效控制该菌引起的感染。
OBJECTIVE To get knowledge of the distribution and drug resistance of Stenotrophomonas maltophilia in our hospital and improve the level of diagnosis and treatment.METHODS Totally 349 strains of S.maltophilia from patients in our hospital from Oct 2008 to Sep 2009 were analyzed to calculate the component ratio and the isolation rate from various departments as well as drug sensitivity.RESULTS S.maltophilia isolated from respiratory department,ICU（intensive care unit）,neurosurgery department and hematology department accounted for 56.4% which mostly originated from sputum and bronchoalveolar lavage fluid.Both of them accounted for 95.5% of all S.maltophilia samples.Up to 70.5% of all the samples were with multiple infection,which comprised one or more pathogens other than S.maltophilia.Drug sensitivity test indicated that TMP/SMX（trimethoprim/sulfamethoxazole） cefoperazone/sulbactam,minocycline and levofloxacin showed the most sensitivity ratio of more than 75.0%.CONCLUSIONS More attention should be focus on S.maltophilia because it shows high drug resistance to many drugs.Early antimicrobial agents susceptibility test is helpful to prevent and control S.maltophilia nosocomial infection.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第14期2158-2160,共3页
Chinese Journal of Nosocomiology
关键词
嗜麦芽寡养单胞菌
多重感染
药敏试验
Stenotrophomonas maltophilia
Multiple infection
Susceptibility test
