摘要
目的了解医院临床标本常见病原菌的分布及其耐药性,为临床合理使用抗菌药物提供依据。方法用纸片琼脂扩散法(K-B法)对医院2006年1-12月各类感染标本中分离的859株病原菌进行药敏试验,同时进行大肠埃希菌、克雷伯菌属超广谱β-内酰胺酶(ESBLs)和耐甲氧西林葡萄球菌(MRS)检测。结果医院分离的病原菌主要为大肠埃希菌、葡萄球菌属、铜绿假单胞菌、克雷伯菌属、不动杆菌属和肠球菌属;大肠埃希菌、克雷伯菌属ESBLs检出率分别为32.8%和29.4%,产ESBLs株对抗菌药物的敏感率明显降低;亚胺培南是对革兰阴性杆菌作用最强的一种抗菌药物,头孢哌酮/舒巴坦、哌拉西林/他唑巴坦也有较好的抗菌活性;耐甲氧西林金黄色葡萄球菌和耐甲氧西林凝固酶阴性葡萄球菌的检出率分别为32.6%和40.7%;革兰阳性球菌对万古霉素敏感性最好,未检出耐万古霉素肠球菌(VRE)。结论重视病原菌耐药性,合理使用抗菌药物。
OBJECTIVE To investigate the distribution of clinical commonly encountered pathogens and their drug resistance in our hospital, and provide reference for reasonable choices of the clinical antibiotics. METHODS The K-B method was used to test the sensitivity to antibiotics of 859 strains pathogens isolated from all kinds of infected samples during from Jan to Dec 2006 in our hospital, at the same time the ESBLs of Escherichia coli and Klebsiella and the MRS were detected. RESULTS The more pathogens isolated from our hospital were E. coli, Sta ph ylococcus , Pseudomonas aeruginosa , K lebsiella , Acinetobacter and Enterococcus. The ESBLs isolating rate was 32.8% in E. coli and 29.4% in Klebsiella, and the sensitivity to antibiotics was degraded obviously in those ESBLs producing strains. Imipenem was the most effective antibiotic to Gram-negative bacilli, cefoperazone/ sulbactam and piperacillin/tazobactam also had better antibacterial activity. The isolating rate of MRSA and MRCNS was 32. 6%and 40. 7% in S. aureus and MRCNS. Gram-positive cocci had the best sensitivity to vancomycin. There was no drug-resistant Enterococcus strain to vancomycin being found. CONCLUSIONS We should think highly of the bacterial drug resistance and use antibiotics reasonably.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2008年第5期716-718,共3页
Chinese Journal of Nosocomiology
