摘要
目的探讨精神分裂症与自身抗体的关系。方法测定了精神分裂症１００例，正常人６１人的血清抗甲状腺球蛋白抗体（ＴＧＡ）、抗甲状腺微粒体抗体（ＴＭＡ）、抗心磷脂抗体（ＡＣＡ），抗脑抗体（ＡＢＡｂ）和抗胰岛素抗体。结果精神分裂症患者血清自身抗体阳性率均偏高；总阳性率为６６％，有２种以上自身抗体者占４６％，均明显高于正常人（Ｐ＜００５）。结论精神分裂症存在自身免疫倾向；自身抗体在精神分裂症的发病机制中，可能起重要作用。
Objective To investigate the relationship between
schizophrenia and autoantibodies.Methods The antibodies of antithyroglobulin(TGA),
antithyroid microsome (TMA), anticuorin(ACA), antibrain(ABAb) and anti insulin(IAb) in serum of
100 patients with schizophrenia and 61 normal controls were detected.Results The
positiveness of the autoantibodies in serum of the patients was 66% and 46% of them had more
than one of the autoantibodies,both of which were significantly higher than that of the normal
controls.Conclusions There is a tendency of autoimmunity in the patients with
schizophrenia.Autoantibodies may play an important role in the pathogenisis of schizophrenia.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
1999年第1期40-41,共2页
Chinese Journal of Nervous and Mental Diseases
