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中枢神经系统疾病患者血清自身抗脑抗体测定 被引量:5

Detection of auto brain antibodies in serum of patients with disorder of central nervous system
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摘要 目的:检测几种中枢神经疾病患者血清中的自身抗脑抗体。方法:用部分纯化的人脑抗原包被微孔塑料测定板,建立测定抗脑抗体的间接 E L I S A 法。结果:血清中自身抗脑抗体的检出率( % ) 在健康正常人( n = 509) 为1 .4 ,在精神分裂症( n =65) 、脑血管意外瘫痪患者( n = 51) 和先天性脑发育不全痴呆症( n = 22) 分别为41 .5 、37 .3 和9 .1 ;而在脑肿瘤和脑外伤患者的检出率则分别为1/6 和2/9 。结论:结果表明,用本文 E L I S A 法检测血清自身抗脑抗体在正常人中的阳性率很低,在精神分裂症和脑血管意外瘫痪患者的检出率较高,可能与其病变过程有关。 Objective:To detect auto antibodies to brain antigen in serum of patients with disorder of central nervous system.Methods:By using microwell titer plate coated with partial purified human brain antigen and horseradish enzyme conjugated SPA, indirect ELISA was employed to detect auto antibody to brain antigen in serum.Results:The positive rate(%) of auto antibodies to brain antigen in serum of healthy normal subjects was 1.4, and whereas the detected rates in patients with schizophrenia, and paralysis caused by cerebral vascular accident were 41.5 and 37.3, respectively, the positive rates of the auto antibodies in patients with congenital dementia, brain tumor, and brain injury were 2/22, 1/6, and 2/9, respectively.Conclusions:The positive rate of auto antibodies to brain antigen in serum of normal subjects was very low,and that of patients with schizophrenia and cerebral vascular accident were relatively higher, which may be related to process of the diseases.
出处 《蚌埠医学院学报》 CAS 1999年第6期380-381,共2页 Journal of Bengbu Medical College
基金 安徽省教育委员会自然科学研究资助
关键词 自身抗体 中枢神经系统 血清诊断 auto antibodies schizophrenia brain hemorrhage
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