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探讨孤立病灶的脱髓鞘及多发性硬化患者与血清谷氨酸脱羧酶抗体的相关性 被引量:1

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摘要 目的探讨血清谷氨酸脱羧酶抗体(GAD-ab)在中枢神经系统炎性脱髓鞘性疾病中的变化。方法选临床确诊的26例多发性硬化(MS)患者为CDMS组和30例临床孤立病灶综合征(CIS)患者为CIS组,空腹采血测定血清中GAD-ab的阳性率与健康体检组30例进行比较。结果CDMS组GAD-ab阳性率为46.1%明显高于CIS组的30.0%(P<0.05),且2组阳性率明显高于健康体检组(P<0.01)。CIS组随访5年,阳性者发展为CDMS的例数比例为78%,明显高于阴性者的38%(P<0.05)。结论检测中枢神经系统炎性脱髓鞘性疾病中GAD-ab,可为MS的诊断提供依据,且助于提高对该病的认识。
出处 《临床合理用药杂志》 2009年第6期47-48,共2页 Chinese Journal of Clinical Rational Drug Use
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