摘要
目的了解医院铜绿假单胞菌感染的分布及药敏情况,为临床治疗提供依据。方法应用回顾性调查方法,对本院2007年~2008年临床送检标本中分离出的铜绿假单胞菌及药敏结果进行统计分析。结果检出铜绿假单胞菌256株。主要分布：重症监护病房（ICU）占41%,神经内科占12.1%,呼吸内科占11%。标本来源主要是痰及咽拭子160株（62.5%）,伤口拭子31株（12.1%）。药敏结果显示铜绿假单胞菌对β-内酰胺类、氨基糖苷类、喹诺酮类和磺胺类抗菌药物有很高的耐药性,耐药率超过50%。对碳青酶烯类、β-内酰胺类与含酶抑制剂复合药耐药率较低,最低是哌拉西林/他唑巴坦8.2%,其次是美罗培南14.1%。结论铜绿假单胞菌主要引起呼吸道和创面感染,多重耐药严重,临床应注意合理使用抗生素并加强对细菌耐药性的全面监测。
Objective To investigate the distribution and drug resistance of clinical pseudomonas aeruginosa isolated,and offer reasonable experimental data for clinical therapy. Methods Retrospectvely survey and statistical analysis were carried out in pathogenic strains and drug sensitive tests of antibioties of pseudomonas aeruginosa isolated in Nanhua hospital from Jan 2007 to Dec 2008. Results Among 256 strains 160（62.5%） come from sputum and throat mucus,and 31（12.1%） from wound swab,the proportion of these strains from ICU,neurology department and respiratory department was 41%、12.1% and 11%.The result of drug susceptibility showed that pseudomonas aeruginosa had a more than 50% resistance rate to the β-lactamases,aminogyeosides,fluoroquinolones and sulfanilamides antibiotics,respectively,a lower resistance rate to carbpenem,β-lactamases,antibiotics/inhi-bitor,and the lowest is to piperacillin/tazobanctam（8.2%） and to meropenem（14.1%）. Conclusions Pseudomonas aeruginosa causes mainly respiratory tract and wound infection,and was highly resistant to some antibiotics.Thus to strengthen the monitoring of the antibiotic resistance and rational utilization of antibiotics of great importance,antibiotics should be used reasonably and all-round supervision of drug resistance should be strengthened.
出处
《南华大学学报（医学版）》
2010年第1期112-114,共3页
Journal of Nanhua University(Medical Edition)
关键词
铜绿假单胞菌
抗菌药物
耐药性
pseudomonas aeruginosa
antibiotic
drug resistance
