摘要
目的:了解奥氮平对精神分裂症患者甲状腺素水平的影响。方法:随机抽取正在服用奥氮平的住院精神分裂症患者20例,分别于入组时、入组后1个月查FT3、FT4、TSH并进行比较。结果:入组时与常模比较FT3显著下降(P<0.01);1个月后与常模比较FT3、FT4显著下降(P<0.01);入组时与1个月后比较FT4显著下降(P<0.01);TSH与年龄、剂量、服用时间正相关(r>0.3);FT3、FT4、TSH与性别无相关性。结论:奥氮平可致甲状腺激素水平下降,TSH有反馈性升高趋势,但尚在正常范围内。临床或许可以通过干预甲状腺激素水平来调整精神分裂症患者的情绪障碍。
Objective： To understand the effect of olanzapine on the levels of thyroid hormones in schizophrenic patients. Method ：Twenty inpatients with schizophrenia who received olanzapine therapy were selected randomly and tested FF3,FT4,TSH at the beginning of treatment and after 1 month treatment . Results： Compared with the norm,FT3 level of the patients decreased significantly at the beginning of treatment（P 〈0. 01 ）, and FT3,FT4 levels decreased significantly after 1 month treatment（P 〈0. 01 ）. FT4 level decreased more significantly after 1 month lreatment for （P 〈 0.01 ）. TSH level was positively correlated with age,dose,time of taking olanzapine （r 〉 0.3 ） , and there were no relationship between FT3, FT4 ,TSH levels and gender. Conclusion： Olanzapine might cause a reduction of t thyroid hormone levels. Perhaps the mood symptoms of schizophrenia eouht be adjusted by regulating thyroid hormone.
出处
《临床精神医学杂志》
2010年第2期121-122,共2页
Journal of Clinical Psychiatry
基金
2008年昆山市社会发展科技计划指令性项目([2008]79-22)
