摘要
目的:探讨抗精神病药致高泌乳素血症的发生情况,为药物流行病学提供参考。方法:对2009—2011年从中山大学附属第三医院精神科收集到的抗精神病药所致60例高泌乳素血症病例,从患者年龄、性别、原患疾病、使用的药物及其发生高泌乳素血症的频次、临床表现及处理措施等方面进行分析。结果:高泌乳素血症仍是目前大多数抗精神病药常见的药品不良反应,其中氟哌啶醇、氯氮平、利培酮、氯丙嗪的发生频率较高,特别是需要合并使用注射剂控制精神病急、重症发作时容易发生。结论:临床医师在处方抗精神病药时应注意定期检测患者的血清泌乳素,及时发现高泌乳素血症患者,并给予合理干预措施,特别是在出现临床症状时,这对于患者病情改善及提高其生活质量有着重要意义。
OBJECTIVE：To investigate the occurrence of hyperprolactinemia induced by antipsychotic drugs so as to provide reference for pharmacoepidemiology.METHODS： The related data of 60 inpatietns with hyperprolactinemia induced by antipsychotic drugs collected in the psychiatric-department of the Third Affiliated Hospital of Sun Yat-sen University during 2009-2011 were analyzed with regard to patients＇age and sex,primary disease,drugs used and the frequency of hyperprolactinemia induced by antipsychotic drugs,clinical symptoms and management of hyperprolactinemia.RESULTS： Hyperprolactinemia was still a common adverse drug reaction of the majority of antipsychotic drugs,with haloperidol,clozapine,risperidone and chlorpromazine topping the list in terms of frequency of hyperprolactinemia especially,especially when concurrent use of injections was needed to control emergent or critical psychiatric episodes.CONCLUSION： Clinicians should give regular monitoring on patients＇ serum prolactin during administration of antipsychotic drugs so as to timely detect the presence of hyperprolactinemia in the patients and take reasonable intervention measures,particularly at the onset of clinical symptoms,which is of significance to improve patients＇ state of disease and quality of life.
出处
《中国医院用药评价与分析》
2012年第10期938-940,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
高泌乳素血症
抗精神病药
不良反应
Hyperprolactinemia
Antipsychotic drug
Adverse drug reaction
