摘要
目的:初步确定狗肝菜保肝护肝的有效活性部位。方法:用CCl4制备小鼠急性肝损伤模型,对4个不同极性部位萃取物进行药效学筛选。结果:狗肝菜正丁醇萃取物和水萃取物可明显抑制急性肝损伤小鼠血清中ALT,AST和MDA活性(P<0.01,P<0.05),升高SOD活性(P<0.05)。结论:正丁醇部位和水部位为狗肝菜保肝的药效学活性部位。
Objective： To search pharmacody namic active extracts of Dicliptera chinensis for protecting liver.Method： Rats cute liver injury model was induced by CCl4 to screen the liver protection of four different fraction extracted from an ethanol extract of D.chinensis.Result： The n-butanol fraction and water fraction can prevent the increase of the ALT,AST and MDA（P0.01,P0.05）,and increase the SOD compared to the normal groups（P0.05）.Conclusion： The results show that the pharmacody namic active extracts of D.chinensis are the n-butanol and water fractions.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2010年第4期497-498,共2页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(30860393)
关键词
狗肝菜
保肝护肝
活性部位
Dicliptera chinensis protecting liver active parts
