摘要
目的了解2005年至2008年本院临床分离菌9005株对常用抗菌药物的耐药性。方法用纸片Kirby-Bauer法,对本院4年分离的9005株临床分离株进行药物敏感性试验,Whonet 5.4统计软件对数据进行分析。结果革兰阴性杆菌数量多于革兰阳性球菌。4年间,肺炎链球菌19株为青霉素不敏感株,β溶血链球菌未见青霉素耐药菌株,流感嗜血杆菌β内酰胺酶产酶率从2005年的13%下降至2008年的4.5%;未发现对万古霉素、利奈唑胺不敏感的葡萄球菌;屎肠球菌的耐药性高于粪肠球菌,万古霉素耐药的肠球菌(VRE)分离率有上升趋势;于2005至2008年,大肠埃希菌的产超广谱β内酰胺酶(ESBLs)分离率分别占43.0%,21.3%,52.0%及52.6%,肺炎克雷伯菌的ESBLs分离率分别占15.0%,25.9%,18.3%及25.0%;铜绿假单胞菌和不动杆菌属已出现多重耐药株。结论定期进行耐药监测有助于了解细菌耐药性变迁。
Objective To analyze the antibiotic resisitance of clinic isolated bacteria in Beijing Hospital from 2005 to 2008. Methods Making antibiotic sensitivity test of total 9005 strains isolated from patients in Beijing Hospital from 2005 to 2008 with K-B method; analyzing the data with Whonet 5.4 system. Results The total strains of gram negative bacilli were more than gram positive coccus. There are 19 Penicillin nonsusceptible S. pneumoniae （PRSP）. As to hemolytic streptococcus, none of them was resistant to penicillin. The β-lactamase producing rate of Haemophilus inflnenzae was decreased from 13% in 2005 to 4.5% in 2008. During 2008, the methicillin - resistant Staphylococcus aureus （MRSA） was 76. 8% and that of methicillin - resistant coagulase - nagerive Staphylococcus （MRSCoNS） was 69.0%. Vancomycin and linezolid resistance strains did not appear. The resistance rate of Enterococcus faecium was higher than that of Enterococcus faecalis. The resistant rates of Enterococcus. to vancomycin and teicoplanin had increasing tendency. The detection rate of extended - spectrum beta - lactamases （ESBLs） to E. coli was 43.0%, 21.3%, 52.0% and 52. 6% in 4 years. The detection rates of ESBLs to Klebiella pneumonia was 15.0% 25.9%, 18. 3% and 25. 0% Multi-antibiotic resistant strains of Pseudomonas aeruginosa and Acinetobacter appeared. Conclusion In order to study the resistance and its tendency of bacteria isolated from patients in Beijing Hospital and offer the theory to clinicalians for experienced treat.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2010年第1期57-63,共7页
The Chinese Journal of Clinical Pharmacology
基金
北京医院青年基金资助项目(BJ-2008-70)
关键词
细菌耐药性监测
耐药性
antibiotic resistance monitor
resistance
