摘要
目的综述细菌生物膜(bacterial biofilm,BBF)在慢性骨髓炎形成中的作用及其防治。方法查阅近年国内外有关慢性骨髓炎和BBF的相关文献,对BBF在慢性骨髓炎形成中的作用以及防治进行回顾及综合分析。结果慢性骨髓炎的诊治至今仍很棘手,除局部瘢痕增生、血供差、耐药菌等原因外,BBF的形成也是重要原因之一。BBF在坏死软组织、骨组织表面形成,对细菌具有保护作用,大大增强了细菌对抗生素的抵抗力,导致细菌难以彻底清除,骨髓炎反复发作感染。BBF的生长包括黏附、发展和成熟3个阶段。作为慢性骨髓炎的主要致病菌之一的葡萄球菌,在形成BBF的过程中有其独自特点,根据这些特点设计治疗方案已成为抗BBF感染治疗的一个趋势。结论目前有大量以BBF形成过程中的关键因子为靶点的治疗研究,但迄今为止手术彻底清除坏死骨组织仍是最有效的方法。
Objective To overview the effect of bacterial biofilms（BBF）on the formation of chronic osteomyelitis and the treatment measure.Methods The original articles in recent years about the relationship between BBF and chronic osteomyelitis were reviewed.Results The diagnosis and treatment of chronic osteomyelitis was very difficult,besides hyperplasia of local scar,poor blood supply,drug-resistant,forming of BBF also was an important reason.BBF formed on the surface of necrosis soft tissue and dead bone.Due to the protection of BBF,the bacterium were far more resistant to antimicrobial agents,which caused the recurrence of chronic osteomyelitis.The forming of BBF included three processes which were adhesion,development and maturity.As the major pathogens of chronic osteomyelitis,staphylococcus had its own characteristic.Designing therapeutic programmes according to these characteristics had become the trend of anti-infection treatment of BBF.Conclusion Although there are lots of studies on anti-biofilm due to the key factors during the forming of BBF,the most effective way of anti-biofilm is still debridement.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2010年第1期108-111,共4页
Chinese Journal of Reparative and Reconstructive Surgery
基金
全军医学科学技术研究"十一五"计划科技攻关项目(08G035)~~
关键词
细菌生物膜
慢性骨髓炎
感染
清创术
Bacterial biofilm Chronic osteomyelitis Infection Debridement
