摘要
目的:探讨双链RNA依赖的蛋白激酶(PKR)及核因子-κB(NF-κB)在子宫颈癌中的表达水平及临床意义。方法:采用免疫组化SABC法检测37例子宫颈癌、10例正常子宫颈组织中PKR和NF-κB表达水平,并分析其与子宫颈癌临床病理特征间的相关性。结果:子宫颈癌组织中PKR阳性表达率为64.9%(24/37),正常子宫颈组织为10.0%(1/10),PKR在子宫颈癌中的表达水平较正常子宫颈组织增高(χ2=9.52,P<0.01)。子宫颈癌组织中NF-κB阳性表达率为72.97%(27/37),而正常子宫颈组织中无NF-κB阳性表达,子宫颈癌组织中NF-κB表达较正常子宫颈组织增高(P=0.00)。PKR表达与子宫颈癌患者年龄、病理类型、临床分期、肿瘤组织分化及患者预后无关;而NF-κB表达与临床分期、肿瘤组织分化有关,而与患者年龄、病理类型及患者预后无关。结论:NF-κB异常表达与子宫颈癌的发生、发展有关。
Objective： To investigate the expressions of double-stranded RNA-activated protein kinase （PKR） and nuclear factor-kappa B （NF-κB） in cervical cancer patients, and their clinical significance thereof. Methods： The expressions of PKR and NF-κB were detected by immunohistochemistry （SABC） in 37 cases of cervical cancer and 10 cases of normal cervical tissue. The relationship between clinical pathological features and the expressions of PKR and NF-κB were analysed in patients with cervical cancer. Results： The positive rate of PKR expression was 64.9% （24/37）in cervical cancer tissues, and 10.0%（ 1/10）in normal cervical tissues. The positive rate of PKR expression was higher in cervical cancer group than that of normal cervical group （Х^2 = 9.52,P 〈 0.01 ）.The positive rate of NF-κB expression was 73.0%（27/37）in cervical cancer tissues, but no expression in normal cervical tissues. The positive rate of NF-κB expression was higher in cervical cancer group than that of normal cervical group （P = 0.00）. There was no correlation between expression of PKR and the age, pathological types, clinical stage, histological stage and prognosis. It was found that the expression of NF-κB was associated with clinical stage and histological stage, and no correlation with patient＇s age, pathological types and prognosis. Conclusion： The abnormal expression of NF-κB is related to the onset and progression in cervical cancer patients.
出处
《天津医药》
CAS
北大核心
2009年第8期646-648,共3页
Tianjin Medical Journal
