摘要
为了研究糙海参体内的化学成分,寻找结构新颖具有抗真菌活性的三萜皂苷类成分。应用多种色谱分离技术对糙海参体内的化学成分进行分离纯化,根据化合物的理化性质、波谱数据及化学方法鉴定其结构。分离得到3个三萜皂苷化合物,分别为scabraside A(1)、echinoside A(2)和holothurin A1(3),并对其抗真菌活性进行了研究(1≤MIC80≤16μg·mL-1)。化合物1为新的三萜皂苷化合物,化合物2和3为首次从该海参中分离得到,它们均显示显著的抗真菌活性。
To study the new antifungal active triterpene glycosides of sea cucumber Holothuria scabra. Triterpene glycosides from Holothuria scabra were separated and purified by silica gel chromatography, reversed-phase silica gel chromatography and RP-HPLC. Their structures were elucidated on the basis of spectral data and chemical evidence. Three triterpene glycosides were identified as scabraside A （1）, echinoside A （2） and holothurin A1 （3）. Scabraside A （1） is a new triterpene glycoside, and compounds 2 and 3 were isolated from Holothuria scabra for the first time. They showed antifungal activities （1 ≤MIC80≤16 μg·mL^-1）.
出处
《药学学报》
CAS
CSCD
北大核心
2009年第6期620-624,共5页
Acta Pharmaceutica Sinica
基金
Project supported by the “863” Hi-tech Research and Development Program of China (No2006AA09Z417)
National Natural Science Foundation of China (No20772155)
关键词
糙海参
三萜皂苷
抗真菌活性
Holothuria scabra
triterpene glycoside
antifungal activity
