摘要
目的:研究玉足海参中具有生物活性的三萜皂苷。方法:应用正相硅胶柱色谱、反相硅胶柱色谱和高效液相色谱的方法分离和纯化三贴皂苷,并通过光谱和化学方法鉴定化合物结构。结果:从玉足海参中分离得到7个三萜皂苷,分别鉴定为leucospilotaside A(1),leucospilotaside B(2),leucospilotaside C(3),holothurin B(4),holothurin B2(5),echinoside B(6),andholo-thurin A(7)。结论:化合物2为新的海参三萜皂苷,化合物1,3,5和6为首次从该种海参中分得。
AIM： To find new bioactive triterpene glycosides from the sea cucumber Holothuria leucospilota. METHODS： Column chromatography on silica gel and ODS RP-C18 and HPLC were used for the isolation and purification of triterpene glycosides, and their structures were elucidated on the basis of spectral data and chemical evidence. RESULTS： Seven triterpene glycosides were isolated from the sea cucumber H. leucospilota, and identified as leucospilotaside A （1）, leucospilotaside B （2）, leucospilotaside C （3）, holothurin B （4）, holothurin B2 （5）, echinoside B （6）, and holothurin A （7）. CONCLUSION： Compound 2 is a new triterpene glycoside, and compounds 1, 3, 5 and 6 have been isolated from this sea cucumber for the first time.
出处
《中国天然药物》
SCIE
CAS
CSCD
北大核心
2009年第5期346-350,共5页
基金
supported by the ‘863’ Hi-tech Research and Development Program of China (No.2006AA09Z417)
National Natural Science Foundation of China (No.20772155)~~
关键词
海参
玉足海参
三萜皂苷
Sea cucumber
Holothuria leucospilota
Triterpene glycosides.
