期刊文献+

实验性链脲佐菌素诱导的大、小鼠糖尿病动物模型研究进展 被引量:35

Advances in Experimental Streptozotocin-induced Rodent Models of Diabetes Mellitus
下载PDF
导出
摘要 糖尿病正呈快速上升趋势,而糖尿病的病因、发病机制尚未完全阐明,糖尿病及其并发症的预防和治疗仍不完善。因此,在糖尿病研究领域优化糖尿病实验动物模型的研究,寻找更接近人类糖尿病自然发病过程的动物模型,对于深入研究糖尿病具有重要的科学意义。 The prevalence of both type 1 and type 2 diabetes mellitus have been increasing beyond our prediction. While the etiology and pathogenesis of diabetes mellitus, especially type 2 diabetes, have not been completely clarified, the prevention and treatments of diabetes and its complications have a long way to go for perfect goals. Therefore, improving experimental diabetic animal models and looking for excellent models of human-like pathogenic process of diabetes become much more significant.
出处 《中国比较医学杂志》 CAS 2009年第3期80-82,共3页 Chinese Journal of Comparative Medicine
基金 浙江省科技厅项目(2005F13029) 浙江省医药卫生科学研究基金(2005A003)
关键词 实验性糖尿病 大鼠 小鼠 链脲佐菌素 Experimental diabetes Rat Mouse Streptozotocin
  • 相关文献

参考文献22

  • 1Rees DA, Alcolado JC. Animal models of diabetes mellitus [ J ]. Diabet Med,2005,22(4) :359 - 370. 被引量:1
  • 2Szkudelski T. The mechanism of alloxan and streptozotocin action in B ceils of the rat pancreas[J]. Physiol Res,2001,50(6) :537 - 546. 被引量:1
  • 3Elsner M, Guldbakke B, Tiedge M, et al. Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin [ J ]. Diabetologia, 2000,43 (12) : 1528 - 1533. 被引量:1
  • 4Kroncke KD, Fehsel K, Sommer A, et al. Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso- urea streptozotozin contributes to islet cell DNA damage [ J ]. Biol Chem Hoppe Seyler, 1995,376(3) : 179 - 185. 被引量:1
  • 5Bedoya FJ, Solano F, Lueas M. N-monomethyl-arginine and nicotinamide prevent streptozotocin-induced double strand DNA break formation in pancreatic rat islets [ J ]. Experientia, 1996,52 (4) : 344 - 347. 被引量:1
  • 6Like AA, Rossini AA. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus [ J ]. Science, 1976,193 ( 4251 ) : 415 - 427. 被引量:1
  • 7Yang Z, Chen M, Fialkow LB, et al. The novel anti-inflammatory compound, lisofylline, prevents diabetes in multiple low-dose streptozotocin-treated mice[J]. Pancreas,2003,26(4) :e99 - 104. 被引量:1
  • 8Mensah-Brown EP, Stosic Grujicic S, Maksimovic D, et al. Downregulation of apoptosis in the target tissue prevents low-dose streptozotocin-induced autoimmune diabetes[J]. Mol Immunol,2002, 38(12- 13):941 -946. 被引量:1
  • 9Muller A, Schott-Ohly P, Dohle C, et al. Differential regulation of Thl-type and Th2-type cytokine profiles in pancreatic islets of C57BId6 and BALB/c mice by multiple low doses of streptozotocin [J]. Immunobiology,2002,205(1) :35 - 50. 被引量:1
  • 10Wright JR Jr, Lacy PE. Synergistic effects of adjuvants, endotoxin, and fasting on induction of diabetes with multiple low doses of streptozocin in rats[J]. Diabetes, 1988,37(1) : 112 - 118. 被引量:1

同被引文献312

引证文献35

二级引证文献195

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部