摘要
目的:研究地菍提取物对实验性高血糖小鼠血糖的影响。方法:分别以葡萄糖、肾上腺素、链脲佐菌素(STZ)造成小鼠高血糖模型,动物分为空白、模型、阳性药格列苯脲或盐酸二甲双胍、地菍提取物高、中、低(60,40,20 g.kg-1)剂量组,连续ig给药10 d,观察地菍提取物的的降糖作用。同时观察其对正常小鼠血糖的影响。结果:地菍提取物对正常小鼠血糖无影响,对葡萄糖致高血糖小鼠有显著降糖作用(P<0.05,P<0.01),对肾上腺素致小鼠急性高血糖有显著拮抗作用(P<0.01),地菍提取物高、中剂量对STZ致高血糖小鼠有显著降糖作用(P<0.01,P<0.05)。结论:地菍提取物有显著的降血糖作用。
Objective： To study the effect of aqueous extract from Melastoma dodecandrum on blood glucose in experimental hyperglycemic mice.Method： Glucose,adrenaline or streptozotocin was administrated respectively to induce three types of experimental hyperglycemic models in mice.Blood glucose was determined after ten days＇ administration of the aqueous extract from M.dodecandrum.Result： The aqueous extract from M.dodecandrum.could decrease blood glucose in hyperglycemic mice induced by glucose,adrenaline or streptozotocin,and it had no effect on blood glucose in normal mice.Conclusion： The aqueous extract from M.dodecandrum had effect of lowering blood glucose in hyperglycemic mice.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第20期187-189,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
广西中医药管理局科研课题(gzzc1008)
关键词
地菍
高血糖
血糖
Melastoma dodecandrum
hyperglycemia
blood glucose
