摘要
目的探讨纤维蛋白胶复合β-磷酸三钙/磷酸二氢钙复合人工骨材料修复骨缺损的能力及作为人工关节固定的可能性。方法实验于2007-11/2008-05在南方医科大学珠江医院中心实验室完成。①选用健康成熟新西兰大白兔16只,在双侧股骨外侧髁部建立骨缺损模式,钻取直径4mm,孔深8mm的柱状圆洞。将FG/CPC复合材料随机植入一侧骨缺损处,另一侧骨缺损以CPC植入作为实验对照。②复合型磷酸钙骨水泥组将复合磷酸钙骨水泥(液粉比为0.3)用专用注射器注入骨孔内并使磷酸钙骨水泥外溢,同时加压固定10min直至硬化,对照组同样方法。③于术后2、4、8和12周分别处死新西兰兔(n=4),分别进行大体观察和力学测试。结果16只兔均进入结果分析。FG/CPC人工骨组比CPC骨组能更有效地修复骨缺损;生物力学测定证明不同的水泥组间具有统计学意义(P<0.05),随着时间的延长,实验组复合型骨水泥抗剪切力强于对照组骨水泥。结论FG/CPC复合材料具有良好的骨传导能力、力学特性,有望成为骨组织工程中修复骨缺损和固定人工关节的理想材料。
Objective To evaluate the effect of the composite bone material, fibrin glue （FG） combined with β-tricalcium phosphate （β-TCP）/monocalcium phosphate, in repairing bone defects and assess the feasibility of using this cement for artificial joint fixation. Methods Bone defects were induced in 16 normal adult New Zealand white rabbits at the bilateral femoral lateral condyles where an 8-mm-deep hole （4 mm in diameter） was drilled on each side. The composite FG/calcium phosphate cement （CPC） （solution： power volume ratio of 0.3：1） was injected on one side of the bone defects （experimental group） and pressurized for 10 minutes, and CPC was injected on the other side （control）. The rabbits were sacrificed at 2, 4, 8 or 12 weeks after the operation for gross observation and biomechanical tests. Results The composite material FG/CPC was more effective than CPC for bone defect repair, and biomechanical tests revealed significant differences between them （P〈0.05）. The shear stress of the artificial bone cement in the FG/CPC group was stronger than that in CPC group. Conclusion The FG/CPC composite possesses good biocompatibility and osteoconductivity and may serve as an ideal material for repairing bone defects.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2009年第1期78-81,共4页
Journal of Southern Medical University
基金
南方医科大学珠江医院院长科学基金(2006)
关键词
磷酸钙骨水泥
纤维蛋白胶
生物力学
骨界面
calcium phosphate cement
fibrin glue
biomechanieal test
interface
