摘要
目的观察初诊老年2型糖尿病患者下肢血管病变情况及血浆脂联素的浓度,探讨两者间的关系。方法入选正常组40名;2型糖尿病组66例,其中单纯2型糖尿病36例,合并代谢综合征30例。用ELISA法检测血浆脂联素浓度,多普勒显像观察下肢动脉血流情况。结果正常组血浆脂联素水平高于2型糖尿病组,单纯2型糖尿病组高于合并代谢综合征组(P<0.05)。下肢血管病变以合并代谢综合征组最明显,脂联素浓度与下肢血管病变程度呈负相关。结论脂联素与老年2型糖尿病患者下肢血管病变的发生及发展相关,脂联素可作为早期诊断糖尿病下肢血管病变及预测其预后的参考指标。
Objective To investigate whether concentrations of plasma adiponectin constitute a significant lower extremity artery lesion risk factor in first visit senile patients with T2DM,with particular focus on the relation between plasma concentrations of adiponectin and the development of lower extremity artery disease. Methods Sixty-six first visit senile patients with T2DM were divided into two groups according to condition type： without any other components of metabolic syndrome（group A）（n=36）,combination with metabolism syndrome （group B）（n= 30）.The main parameters include adiponectin level and atherosclerotic plaque. Results Plasma concentrations of adiponectin in group B were significantly lower than those in group A and in the control group（P〈0.05）. Additionally,lower extremity artery lesion is the most obvious in group B that looks like associated with plasma concentrations of adiponectin. Conclusions The findings suggest that measurement of plasma concentrations of adiponectin may be of use for assessing the risk of lower extremity artery disease and may be related to the development of lower extremity artery disease.
出处
《南华大学学报（医学版）》
2008年第5期608-610,共3页
Journal of Nanhua University(Medical Edition)
关键词
2型糖尿病
代谢综合征
下肢血管病变
脂联素
type 2 diabetes
metabolic syndrome
lower extremity artery disease
adiponectin
