摘要
目的:探讨老年2型糖尿病和血清脂联素水平的关系。方法:纳入60例老年2型糖尿病(T2DM)患者和28例健康者为对照组。受试者的临床资料包括年龄、性别、体质指数(BMI)、踝臂指数(ABI)、血清脂联素、糖化血红蛋白(HbA1c)、空腹血糖、胰岛素和血脂等生化指标,同时计算稳态模型的胰岛素抵抗指数和采用多普勒显像测量双侧颈总动脉IMT。结果:2型糖尿病组脂联素和双侧颈总动脉IMT和对照组比较差异有统计学意义。2型糖尿病脂联素与双侧颈总动脉IMT呈负相关。结论:血浆脂联素与2型糖尿病的发生发展密切相关,对其防治有重要临床意义。低脂联素是2型糖尿病的独立危险因素,对其血管病变的发展有重要意义。
Objective To study the correlation between serum adiponectin and type 2 diabetes mellitus(T2DM).Methods Sixty aged patients with type 2 diabetes mellitus were enrolled in and twenty-eight healthy individuals served as a control group in this study.Clinical data including age,sex,BMI,ABI,serum adiponectin,fasting plasma glucose,glycated hemoglobin,insulin and blood lipids were collected Insulin resistance index in Home Model.The intima-media thickness of two common carotid arteries was examined by Doppler at the same time in all cases.Results Serum adiponectin and the intima-media thickness of two common carotid arteries in patients with type 2 diabetes mellitus were statistically different from healthy controls.The serum adiponectin was negatively correlated to the development in patient with T2DM.Conclusion The adiponectin has close relationship with patients with type 2 diabetes mellitus which is significant for prevention and theropy.Low adiponectin concentration is a independent risk factor in type 2 diabetes patients and plays an important role in progressing the vascular pathological changes.
出处
《湖南师范大学学报（医学版）》
2012年第3期42-44,共3页
Journal of Hunan Normal University(Medical Sciences)
关键词
脂联素
2型糖尿病
adiponectin
Type 2 diabetes mellitus
