摘要
为考察伊维菌素长效注射液的急性毒性,用简化寇氏法对小鼠的LD50进行了测定。将伊维菌素长效注射液以1∶0.7的组间剂量给试验小鼠一次皮下注射,连续观察7 d。结果表明,伊维菌素长效注射液的LD50为257.04 mg/kg,95%可信限范围为192.84 mg/kg^342.61 mg/kg,符合低毒标准,说明该药临床皮下注射使用安全。
In order to observe the actue toxicity of long-action Ivermectin injection, modifited Korbor＇ s method was used to study acute toxicity in mice. Mice were injected with different concentrations of longaction ivermectin in a 1 ： 0.7 intergroup doses,and observed for 7 days. The results showed that the LD50 of long-action ivermectin injection was 257. 04 mg/kg, and 95% confidence limit was 192. 84- 342.61 mg/kg. The results confirmed that long-ation ivermectin injection belongs to hypotoxicity and it is safe to inject subcutaneously.
出处
《动物医学进展》
CSCD
2008年第12期41-42,共2页
Progress In Veterinary Medicine
