摘要
目的:研究两面针结晶8的镇痛作用并对其镇痛机制进行初步探究。方法:①采用热板法、扭体法观察结晶8的镇痛效果;②采用HPLC测定小鼠血清及脑组织中的单胺类递质的含量变化。结果:①结晶8高低剂量组均对热板法所至小鼠的疼痛有明显的抑制效果,能使小鼠血清中的5-T含量减少(P<0.05或0.01);②结晶8低剂量组对小鼠的扭体反应有明显的抑制效果,能使小鼠脑内的DA含量减少(P<0.05)。结论:结晶8具有镇痛作用,而镇痛机制可能与其降低脑内DA和外周组织5-HT含量有关。
Objective：To investigate the analgesic effect of the crystal 8 from Zanthoxylum nitidum（Roxh. DC. and study its analgesic mechanism. Methods：（1）The analgesic effect of Crystal 8 was respectively evalu- ated by the writhing test and hot-plate test in mice. （2）The changes of the Monoamine neurotransmitter contents in the serum and brain of the mice were observed by HPLC. Result： （1）In the high dosage group and the low dosage group, the pain threshold value of the mice was enhanced obviously in the hot-plate test and the contents of 5-HT was reduced in their serum. （ P 〈0.05 or 0.01）. （2）In the low dosage group, the writhing times of the mice was reduced markedly and the contents of DA was reduced in the brain of the mice （ P 〈0.05）. Conclusion：The Crystal 8 has markedly analgesic effect and its analgesic mechanism may be related to reduction of the contents of DA in the brain and 5-HT in the peripheral tissue.
出处
《广西医科大学学报》
CAS
北大核心
2008年第5期674-677,共4页
Journal of Guangxi Medical University
基金
高等学校博士学科专项科研基金资助项目(No.20050598003)
