摘要
初步探究美托洛尔(METO)或/和普伐他汀(PRAV)对大鼠二甲双胍(METF)药动学的影响。将28只雄性SD大鼠随机分成METF组、METF+METO组、METF+PRAV组和METF+METO+PRAV组(n=7),于给药后10、20、40、60、90、120、180、240、360、480和600 min股动脉采集血样,采用HPLC测定二甲双胍血药浓度。与METF组相比,METF+METO组二甲双胍C_(max)显著降低(P<0.01),MRT_(0-t)、t_(1/2)和V显著增加(P<0.05);METF+PRAV组t_(1/2)显著降低(P<0.01);METF+METO+PRAV组MRT_(0-t)增加(P<0.05),C_(max)显著降低(P<0.01)。与METF+METO组相比,METF+METO+PRAV组二甲双胍MRT_(0-t)显著降低(P<0.05)。与METF+PRAV组相比,METF+METO+PRAV组二甲双胍C_(max)显著降低(P<0.01),MRT_(0-t)和t_(1/2)显著增加。结果表明,二甲双胍、美托洛尔和普伐他汀在大鼠体内存在多药相互作用。
This study investigates the effects of metoprolol（METO） or/and pravastatin（PRAV） on the pharmacokinetics of metformin（METF） in rats. Twenty-eight male SD rats were divided into METF group,METF＋METO group,METF＋PRAV group and METF＋METO＋PRAV group. Blood samples were collected at 10,20,40,60,90,120,180,240,360,480 and 600 min after oral administration of metformin,and concentration of metformin in plasma was determined by HPLC. Compared to the METF group,C_（max） of metformin was significantly decreased（P〈0.01） and MRT_（0-t）,t_（1/2） and V were significantly increased in the METF＋METO group; t1/2 was significantly decreased in the METF＋PRAV group; Cmax was significantly decreased and MRT0-t was significantly increased in the METF＋METO＋PRAV group. Compared to the METF＋METO group,MRT0-t of metformin was significantly decreased in the METF＋METO＋PRAV group. Compared to the METF＋PRAV group,C_（max） of metformin was significantly decreased（P〈0.01）,and MRT0-t,t1/2 and V were significantly increased in the METF＋METO＋PRAV group. There exist multiple drug interactions of metformin,metoprolol and pravastatin in rats.
出处
《药学学报》
CAS
CSCD
北大核心
2017年第2期253-257,共5页
Acta Pharmaceutica Sinica
关键词
二甲双胍
美托洛尔
普伐他汀
多药相互作用
药动学
metformin
metoprolol
pravastatin
multiple drug interaction
pharmacokinetics
