摘要
目的探讨β-catenin、Survivin蛋白在胆囊癌中的表达及意义。方法免疫组织化学检测90例胆囊良恶性病变中β-catenin、Survivin蛋白的表达，分析与临床病理参数的关系。结果（1）β-catenin在胆囊癌、腺瘤及慢性胆囊炎组织中的阳性率为86．O％、80．O％和25．O％，差异有统计学意义（P〈0．01），与分期、转移、生存时间及病程长短相关（P〈0．05）。（2）Survivin蛋白阳性率分别为64％、20％和10％，差异有统计学意义（P〈0．05），与分期和转移相关（P〈0．05）。（3）两者表达呈正相关（r1=0．298，P〈0．05）。结论（1）Wnt信号通路和细胞黏附功能的异常可能与胆囊癌的发生、发展有关。（2）凋亡可能在胆囊癌的发生、发展中起作用，且Survivin蛋白表达与其不良生物学行为有关。（3）两者可能在胆囊癌的发生、发展中起协同作用。
Objective To investigate the expression of β-catenin and survivin protein in gallbladder carcinoma and the significance. Methods The expression of β-catenin and survivin was detected by immunohistochemistry in 90 cases of gallbladder benign diseases and carcinomas. Results （ 1 ） The abnormal positive expression rate of β-catenin in primary gallbladder carcinoma, adenoma and cholecystitis was 86.0% ,80.0% and 25.0% respectively, with the difference being significant （ P 〈 0.01 ）. The abnormal positive expression of β-catenin in gallbladder carcinoma was closely related with Nevin stage,metastasis, survival time after operation and course of disease （ P 〈 0.05 ） ; （ 2 ） The positive expression rate of survivin in primary gallbladder carcinoma, adenoma and cholecystitis was 64.0% ,20.0% and 10.0% respectively with the difference being significant （ P 〈 0.05 ）. The positive expression of survivin in gall- bladder carcinoma was closely related with Nevin stage and metastasis （ P 〈 0.05 ） ; （ 3 ） In gallbladder carcinoma the abnormal expression of β-catenin had a positive correlation with the expression of survivin （r = 0. 298,P 〈 0.05 ）. Conclusion （ 1 ） Wnt pathway and the loss of cell adhesion may play a role in the occurrence and development of gallbladder carcinoma; （2） Apoptosis may play an important role in the occurrence mad development of gallbladder carcinoma and the overexpression of survivin had a correlation with malignant biological behavior of gallbladder carcinoma; （3） β-catenin and survivin may play a cooperative effect in the occurrence and development of zallbladder carcinoma.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2008年第10期1243-1244,共2页
Chinese Journal of Experimental Surgery
基金
安徽省教育厅科研基金资助项目（KJ20078200）
