摘要
目的 研究缺氧诱导因子-1α（HIF-1α）与Survivin在胃癌及正常胃组织中表达的相互关系，探讨其在胃癌的发生、浸润和转移中的作用。方法 应用免疫组化SP法检测54例胃癌中HIF-1α、Survivin的表达情况，分析HIF-1α、Survivin与胃癌临床病理因素的关系。结果 HIF-1α在胃癌中的表达率74．1％，明显高于正常胃组织（0）（P〈0．01）；HIF-1α的表达与胃癌TNM分期、肿瘤浸润深度和淋巴结转移显著相关（P〈0．05）。胃癌中Survivin高表达（72．2％），且肿瘤浸润深（P〈0．01）、有淋巴结转移（P〈0．05）和临床分期高（P〈0．01）时升高。胃癌组织中HIF-1α与Survivin的表达呈正相关（r=0．31，P〈0．05）。结论 联合检测HIF-1α和Survivin可判断胃癌恶性程度和预后。
Objective To study the expression of HIF-1α and survivin in gastric cancer,and to study their role in tumor angiogenesis,invasion and metastasis. Methods Immunohistochemical technique was used to detect the expression of HIF-1α and survivin in 54 cases of gastric cancer. Results The expression rate of HIF-1α in gastric cancer（74.1% ） was higher than that in normal gastric tissue（0） ,The expression of HIF-1α in gastric cancer was associated with TNM staging,invasive depth and lymph-node metastasis（ P 〈 0.05） ,The expression of survivin in gastric cancers was high （ 72.2% ）, and increased with invasive depth （ P 〈 0.01 ） , clinical stages （ P 〈 0.01 ） and lymphatic metastasis （ P 〈 0.05 ）. There was a positive correlation between expression of HIF-1α and Survivin （ r = 0.31 ,P 〈 0.05 ）. Conclusion HIF-1α and Survivin could be factors in the judgement of the degree of malignancy of gastric cancer and prediction of its prognosis.
出处
《中国综合临床》
北大核心
2008年第9期885-888,共4页
Clinical Medicine of China
基金
辽宁省自然科学基金课题（20072109）
沈阳市自然科学基金课题（1071200-1-00）
