摘要
目的探讨血管内皮生长因子(VEGF)水平与胃癌TNM分期的相关性。方法 ELISA法和免疫组化方法检测VEGF在158例胃癌患者中不同浸润深度(Tis～T4)、不同淋巴结转移程度(N0～N3)及不同远处转移程度(M0～M1)的表达水平,并进行相关性分析。结果血清VEGF水平由Tis～T4呈逐渐升高趋势,相关性显著(r=0.879,P<0.01);并随淋巴结转移程度增高而显著升高,两者显著相关(r=0.834,P<0.01);血清VEGF水平在M0显著低于M1,两者具有相关性(r=0.627,P<0.01)。同样,胃癌组织中VEGF水平与胃癌浸润深度、淋巴结转移及远处转移均显著相关(P<0.01)。结论血清或胃癌组织中VEGF的表达随着胃癌浸润深度、淋巴结转移和远处转移程度的增加逐渐增高,检测VEGF可提示胃癌患者的TNM分期。
Objective To discuss the correlation between the level of vascular endothelial growth factor（VEGF） and TNM staging of gastric cancer.Methods ELISA method and immunohistochemical method were used to detect the expression levels of VEGF with different infiltrating degrees（Tis-T4）,different lymph node metastasis degrees（N0-N3）,and different far metastasis（M0-M1） in 158 cases of gastric cancer.And the correlation was analyzed.Results The level of serum VEGF increased along with the infiltrating degree,and the correlation was significant（r=0.879,P0.01）.The level significantly increased along with the increase of lymph node metastasis degree（r=0.834,P0.01）,and the correlation was significant.The level at M0 was significantly lower than that at M1,and there was a significant correlation between the two ones（r=0.627,P0.01）.Likewise the VEGF level in the gastric cancer tissues was significantly correlated with the infiltrating degree,lymph node metastasis,and far metastasis（P0.01）.Conclusion The expression level of VEGF in serum or gastric cancer tissues increases along with the augmentation of infiltrating,lymph node metastasis,and far metastasis degrees.The detection of VEGF may predict the TNM staging of gastric cancer.
出处
《西南国防医药》
CAS
2012年第12期1291-1293,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
血管内皮生长因子
胃癌
TNM分期
相关性
vascular endothelial growth factor
gastric cancer
TNM staging
correlation
