摘要
TFF3作为胃肠黏膜中一个重要的黏膜保护因子,与胃肠黏膜的损伤、修复、增殖、恶变都有着重要的关系.TFF3与肿瘤的发生、发展、预后有一定的关系,但TFF3的结合蛋白尚未明确,其细胞内作用机制、具体信号转导途径的相关研究尚处于起始阶段.本文对TFF3的研究进展作一综述.
As one of important defensive factors, trefoil factor 3 （TFF3） has considerable relation to the lesion, recovery, proliferation and malignancy of gastrointestinal mucosa. Furthermore, the correlation between TFF3 and tumor, including its pathogenesis, progress and prognosis, has been reported remarkably. However, the binding proteins of TFF3 remains to be confirmed and the research of TFF3 on the mechanism of action and signal transduction pathway is just initial. This article reviewed the progress in TFF3 research.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第20期2267-2273,共7页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.30750013~~
关键词
三叶因子3
肿瘤
信号转导
Trefoil factor 3
Tumor
Signal bansduction
