摘要
三叶因子(trefoil factor,TFF)是一个具有重要功能的多肽家族,生理状态下表达于胃肠道黏膜组织及其他黏膜组织中的分泌细胞.当机体发生消化系统炎症、肿瘤等病理改变时,TFF会伴随病理过程而发生异常表达和/或持续分泌.肿瘤病理学研究资料表明TFF的异常表达与疾病预后相关,而从基因表达谱、肿瘤分泌蛋白谱、生物信息学等多种分析角度出发的研究结果,进一步肯定了TFF多肽检测和TFFmRNA检测在相关疾病的临床实验诊断,特别是在肿瘤复发、肿瘤转移的监测及疗效观察、预后判断等方面,具有良好的实验诊断效能.因此,对于相关疾病的实验诊断,TFF可能是一个潜在的生物学标志物.但其实际应用前景还需要更加充分的、前瞻性的临床研究资料来加以判断.
Trefoil factors （TFF）, expressed physiologically in the secretory cells of gastrointestinal mucosa and other mucosal tissues, compose a unique peptide family with important biologic functions. Aberrant expression and/or continued secretion of TFF might exist concurrently with the processes of digestive system inflammation, tumor or other related pathological changes. Previous pathological studies have shown that the abnormal expression of TFF is associated with the prognosis of digestive system diseases. The results obtained from gene expression profiling, tumor secretomics and bioinformatic analysis have positively confirmed that clinical detection of TFF peptides or mRNAs has an excellent diagnostic performance to detect digestive system diseases, especially for the monitoring of recurrence or metastasis of tumors and for the estimation of therapeutic efficacy and prognosis. Therefore, TFF is a potential biomarker for diagnosis, treatment and prognosis of digestive system diseases.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第26期2794-2799,共6页
World Chinese Journal of Digestology
基金
国家基础研究973基金资助项目
No.2010CB529805
国家基金委重点资助项目
No.30630014
国家基金委面上资助项目
No.30570359
中国科学院重要方向基金资助项目
No.KSCX2-YW-R-088~~
