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溃结安康汤对溃疡性结肠炎模型大鼠MPO水平及ITF mRNA表达的影响 被引量:10

Effects of Kuijie Ankang Decoction on level of MPO and the expression of ITF mRNA in colonic mucosa of ulcerative colitis of rats
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摘要 目的:观察溃结安康汤对大鼠溃疡性结肠炎(UC)的治疗作用,并探讨其可能机制。方法:48只清洁级SD大鼠随机分为4组:正常组、模型组、溃结安康汤组、柳氮磺吡啶(SASP)组。造模并治疗21d后,进行疾病活动指数(DAI)评分,观察结肠HE染色病理涂片,髓过氧化物酶(MPO)水平,以及肠三叶因子(ITF)mRNA表达。结果:与模型组相比,溃结安康汤组DAI评分显著降低(P<0.01),结肠HE染色病理示炎症细胞明显减少,MPO水平显著降低(P<0.01),ITF mRNA表达显著升高(P<0.01)。结论:溃结安康汤可以显著改善UC大鼠症状、病理形态,通过降低MPO水平,上调ITF mRNA表达,从而达到抑制炎症的效果。 Objective:To observe the therapeutic effect of Kuijie Ankang Decoction on ulcerative colitis(UC)in rats and explore its possible mechanism.Methods:Forty-eight clean SD rats were randomly divided into four groups:normal group,model group,Kuijie Ankang Decoction group and SASP group.After 21 days of treatment,disease activity index(DAI)was scored to observe the expression of intestinal trefoil factor(ITF)and myeloperoxidase(MPO)in HE stained pathological smears of colon.Results:Compared with the model group,the DAI score of Kuijie Ankang Decoction group was lower(P<0.01),the inflammatory cells and MPO levels were significantly reduced(P<0.01),and the expression of ITF mRNA was significantly increased(P<0.01).Conclusion:Kuijie Ankang Decoction can significantly improve the symptoms and pathological morphology of UC rats.It can inhibit inflammation by lowering MPO level and increasing ITF gene expression.
作者 李楠 柳越冬 王长洪 崔世超 张晓明 LI Nan;LIU Yue-dong;WANG Chang-hong;CUI Shi-chao;ZHANG Xiao-ming(Graduate School,Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China;The Third Clinical College,Liaoning University of Traditional Chinese Medicine,Shenyang 110003,China;Traditional Chinese Medicine Department,The General Hospital of Shenyang Military,Shenyang 110016,China)
出处 《中华中医药杂志》 CAS CSCD 北大核心 2019年第7期3005-3008,共4页 China Journal of Traditional Chinese Medicine and Pharmacy
基金 国家自然科学基金项目(No.81072819)~~
关键词 溃结安康汤 溃疡性结肠炎 髓过氧化物酶 肠三叶因子 炎性反应 机制 Kuijie Ankang Formula Ulcerative colitis MPO ITF Inflammatory reactions Mechanism
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