摘要
目的采用逆向混合搅拌法对β-环糊精(简称β-CD)包合蛇床子超临界萃取产物的工艺参数进行优选。方法采用正交实验设计,以包合物产率及包合率两个指标,综合考察β-CD与萃取物、β-CD与水的比例、包合温度、搅拌时间等四因素对包合工艺的影响,并对包合物的形成进行了物相鉴别。结果最佳包合工艺为A2B2C2D3。即β-CD与萃取物的比例为2∶1(g∶g),包合温度为50℃,包合时间为6 h,β-CD与水的比例为1∶32(g:m l)。结论优选出的包合工艺合理、可行,且包合物产率、包合率较高。
Objective To optimize the including preparation for extracts of Fructus Cnidii by SFE - CO2 with β - CD by using self - drafting test of counter mixture stirring. Methods An orthogonal test was designed to optimize the process with the ratios of inclusion complexation and productivity as indexes, Four factors, such as the ratio of β - CD to txtracts of fructus Cnidii, the ratro of β - CD to the volume of water, temperature and time were investigated. The inclusion compound was proved. Results The optimal technology of inclusion complexation was A2 B2 C2 D3. Ratio of β - CD to extracts of fructus Cnidii was 2： 1 （ g/g）, the temperature was 50℃ ,the time was 6 hours and the rates of β - CD to the volume of water was 1： 32（g/ml ）. Conclusion The including technology is suitable , reliable and can gain the high ratio of inclusion complexation and productivity.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2008年第4期979-980,共2页
Lishizhen Medicine and Materia Medica Research
关键词
蛇床子超临界二氧化碳萃取物
Β-环糊精包合
逆向混合搅拌法
正交实验
Extractives of Fructus Cnidii by SFE - CO2
β - CD compound
Self - drafting test of counter mixture stirring
Orthogonal test
