摘要
目的介绍富血小板血浆(platelet-rich plasma,PRP)及其在骨科领域的应用。方法查阅国内外近年来PRP制备、生理机制及其在骨科领域最新应用的文献,并进行回顾和综合分析。结果PRP具有促进组织愈合及促进骨再生等功能,缺点是缺乏标准的制备方法,PRP所含生长因子和蛋白质数量以及各种生长因子的相互作用机制仍不明确。临床应用前仍需建立可靠的动物模型和标准化的临床试验。结论PRP在骨科领域有着广泛的应用前景。
Objective To introduce the current situation of platelet-rich plasma （PRP） and its application in orthopedics field. Methods The latest literature was reviewed, concerning the preparations of PRP, physiological mechanism and the latest applications in orthopedics field. Results PRP represent a new biotechnology for the stimulation and acceleration of tissue healing and bone regeneration. To succeed, some of the challenges need to be addressed including standardization and definition of the different PRP preparations, the complete characterization of the platelet released factors and proteins. Furthermore, well-designed studies and clinical trials are needed to evaluate the potential therapeutic impact of PRP. Conclusion PRP provides a novel application for orthopedics field.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2008年第7期880-883,共4页
Chinese Journal of Reparative and Reconstructive Surgery
关键词
富血小板血浆
骨科
应用进展
Platelet-rich plasma Orthopedics Application development
