摘要
目的探讨远航对舰艇官兵免疫功能和营养状况的影响。方法用流式细胞仪和日立模块式7600全自动血生化分析仪对173名舰艇官兵远航前后T、B、NK淋巴细胞亚群(包括CD3+、CD3+CD4+、CD3+CD8+、CD4+/CD8+、CD3-CD19+和CD3-CD56+等6项免疫指标)和血清总蛋白(TP)、白蛋白(ALB)、葡萄糖(Glu)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白A2(ApoA2)、载脂蛋白B(ApoB)、载脂蛋白C2(ApoC2)、载脂蛋白C3(ApoC3)、载脂蛋白E(ApoE)、脂蛋白a[LP(a)]及血清铁(Fe2+)、总铁结合力(TIBC)、血红蛋白(Hb)、钾(K+)、钠(Na+)、氯(Cl-)、钙(Ca2+)、镁(Mg2+)等指标进行了检测。结果与航前比较,舰艇官兵CD3+淋巴细胞、CD3+CD4+淋巴细胞、CD4+/CD8+均显著升高(P<0.05),CD3+CD8+淋巴细胞显著降低(P<0.05)。Glu、ApoC2水平显著升高(P<0.01),ApoA2水平升高(P<0.05),TC、LDC-C、ApoB、LP(a)水平显著降低(P<0.01);总铁结合力水平升高(P<0.05),TP、ALB、Hb水平显著降低(P<0.01),血清Fe2+水平降低(P<0.05),Mg2+水平升高(P<0.05),Na+、Ca2+水平显著降低(P<0.01)。结论远航期间舰艇官兵免疫力提高,白蛋白和血清Fe2+、Na+、Ca2+水平降低,应给予及时补充。
Objective To investigate the effects of sea voyage on cellular immune function and nutrition status of naval servicemen. Methods A total of 173 male naval servicemen were included in the present study. The percentage of T, B and NK cell subpopulations from peripheral blood were assessed by flow cytometry. CD3^＋, CD3^＋CD4^＋, CD3^＋CD8^＋ and CD4^＋/CD8^＋ were employed as the markers of T cell subpopulation, CD3-CD19^＋ served as the marker of B cell subpopulation, and CD3-CD56^＋ served as the marker of NK cell subpopulation. The serum total protein （TP）, albumin （ALB）, glucose （Glu）, total cholesterol （TC）, triglyceride （TG）, high-density lipoprotein cholesterol （HLD-C）, low-density lipoprotein cholesterol （LDL-C）, apolipoprotein A1 （ApoA1）, apolipoprotein A2 （ApoA2）, apolipoprotein B （ApoB）, apolipoprotein C2 （ApoC2）, apolipoprotein C3 （ApoC3）, apolipoprotein E （ApoE）, lipoprotein a （LPa）, Fe^2＋, total iron-binding capacity （TIBC）, Hb, K^＋, Na^＋, Cl^-, Ca^2＋ and Mg^2＋ levels were determined by 7600DDP. Results Compared with that before sailing, the percentage of CD3＋, CD3＋CD4＋ and CD4＋/CD8＋ elevated significantly during voyage （P〈0.05）; CD3＋CD8＋ plummeted markedly （P〈0.05）; Glu and APOC2 levels were elevated markedly compared with those before sailing （P〈0.01）; APOA2 level was higher than that before sailing （P〈0.05）; TC, LDC-C, APOB and LPa levels were lowered markedly than those before sailing （P〈0.01）; TP, ALB and Hb levels were lowered markedly than those before sailing （P〈0.01）; Fe2＋ level was lowered （P〈0.05）; Na＋ and Ca2＋ levels were lowered markedly than those before sailing （P〈0.01）. Conclusion The present study has revealed that cellular immune function of naval servicemen can get significantly improved during navigation. TP, ALB, Fe^2＋, Na^＋ and Ca^2＋ levels are lowered markedly compared with those before sailing （P〈0.01）, therefore it is ne
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2008年第5期617-619,共3页
Medical Journal of Chinese People's Liberation Army
基金
军队“十一五”专项项目课题(06Z053)
关键词
海军医学
免疫活性
营养状况
naval medcine
immunocompetence
nutritional status
