摘要
载脂蛋白E(APOE)ε4等位基因是阿尔茨海默病(AD)的危险因素之一。2009年7月发表在《新英格兰医学杂志》(N Engl J Med)上的一项多中心纵向队列研究提示:APOEε4等位基因携带者在60岁之前开始出现记忆力衰退,且该等位基因对记忆力的影响独立于轻度认知障碍和痴呆。由于血管性因素在AD的发生、发展中起着重要作用,而高血压、糖尿病及APOEε4基因分型对中老年期认知衰退均有独立的贡献,我们认为不能排除血管性因素对文中报道的记忆力衰退的影响。
The apolipoprotein E （APOE） ε4 allele is one of the genetic risk factor for Alzheimer＇s disease （AD）. A multicenter longitudinal study published in ＂N Engl J Med＂ suggested that age-related memory decline in ,4POE ε4 carriers diverges from that of noncarriers before the age of 60 years. Vascular factors may play an important role in the development of AD. Diabetes, hypertension, and the APOE ε4 genotype independently contribute to cognitive decline in late middle age and beyond. We argued the possibility that these risk factors could have an effect on the reported memory decline cannot be ruled out.
出处
《医学争鸣》
CAS
北大核心
2010年第5期17-20,共4页
Negative
