摘要
[目的]观察不同胃溃疡模型大鼠是否存在各自特殊的证候,以及同病异证和异病同证。[方法]采用应激法(水浸拘束)、消炎痛法、利血平法、乙醇法等4种常用不同方法建立大鼠胃溃疡疾病模型,并设置空白及禁食对照,运用我们业已建立的大小鼠标准化、计量化的四诊检测和辨证方法,对以上各模型进行了客观、动态、量化的检测和证候评价。[结果](1)不同造模方法大鼠存在特殊证候,例如水浸拘束模型气血阴阳损伤程度轻,恢复快;消炎痛模型有典型的胃寒证、气阴阳虚证复合证表现等。(2)在同病异证方面,同一大鼠,疾病的不同阶段存在证候的演变,且同一疾病,不同大鼠存在显著的证候差异。如乙醇造模后第2天,不同大鼠分别表现为阴虚、阳虚,气虚及阴阳两虚证等。(3)在异病同证方面,不同疾病大鼠在相同阶段可以出现类似的证候表现,且不同疾病模型在不同阶段出现类似的证候表现,如消炎痛、利血平等不同疾病大鼠可以出现相似的胃寒证、气虚及阴阳两虚证表现。[结论]不同胃溃疡模型大鼠存在各自的证候特点,及"同病异证、异病同证"的现象。可以推测,实施"同病异治"和"异病同治"将有助于提高疗效。
[Objective] To investigate and discuss if there are special syndromes, same disease but different syndromes and same syndrome but different diseases in the different gastric ulcer rat models. [Methods] Based on reports, we select fourmethods-stress,antifani, apoplon, and alcohol to make gastric ulcer model simultaneously, and set up the normal and control groups. Then we use the standardized and quantified four diagnostics and differentiation methods for mice, which are established to examine and appraise the above models in an objective, dynamic and quantified way. [Result] First, different mice models have different syndromes, such as in the water immersion model,damage to Qi blood Yin and Yang was slight and recovered quickly. The anti-fani model, with typical syndromes of cold in the stomach,is a compound model of Qi, blood, Yin and Yang deficiency second,there exists syndrome evolution in the disease diversity stage in the same rat moreover, significant syndrome difference exists for the same disease in different rat. For example,on the second day after the alcohol was given to the rats,there was Yin deficiency,or abundance of Qi, or deficiency in both Yin and Yang to the different individual. Thirdly,as for same syndrome but different disease, similar syndromes appear on the same stage in different diseases, as well as the similar syndrome appear on the different stage in different diseases. For instance, the anti-fani model and the apoplon model have similar syndromes of cold in the stomach, Qi deficiency, Yin and Yang deficiency. [Conclusion] There exist respective syndromes in different gastric ulcer mice models. We can infer that to put into practice＂treating the same disease with different methods＂and＂treating different diseases with same method＂will help improve the curative effect.
出处
《浙江中医药大学学报》
CAS
2008年第3期317-320,共4页
Journal of Zhejiang Chinese Medical University
基金
上海市科委国际合作项目(No:064307052)
2006上海市教委学科建设项目
上海高校选拔培养优秀青年教师科研专项基金资助项目~~
关键词
胃溃疡
证候
同病异证
异病同证
大鼠
动物模型
gastric ulcer syndrome characteristics same disease but different syndromes same syndrome but different diseases rats animal model
