摘要
目的:合成酮洛芬。方法:以3-氰甲基苯甲酸为起始原料,经过Friedel-Crafts、单甲基化、水解3步得酮洛芬。结果:总收率为73.8%,目标产物纯度为99.8%。结论:本合成路线成本低、收率高,适合工业化生产。
Objective： To investigate the synthesis of ketoprofen. Methods： Started from 3-cya-nomethylbenzoic acid, the ketoprofen was synthesized via 3-step reactions, i.e. Friedel-Crafts, α-monomethylation and hydrolysis. Results： The total yield of ketoprofen was 73.8% and the purity was 99.8%. Conclusion： This new synthetic procedure with lower cost and higher yield is suitable for industrial production.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2008年第8期673-674,678,共3页
Chinese Journal of New Drugs
