摘要
以２－甲氧基萘为起始原料，经氯代、氯甲基化、氰化、水解制成２－（５－氯－６－甲氧基－２－萘基）乙酸（４），再经固－液相转移催化直接进行α－单甲基化、脱氯即得ｄｌ－萘普生（１），总收率５１．７％。此法原料易得，操作简便，适合工业化生产。
dl-Naproxen was synthesized from 2-methoxynaphthalene via chloronation, chloromethylation, cyanation, hydrolysis, solid-liquid phase-transfer catalytic α-methylation and dechloronation with a total yield of 51.7%. This method has the advantages of simpler work-up, milder reaction condition and it is applicable to large-scale preparation.
出处
《华西药学杂志》
CAS
CSCD
北大核心
1995年第3期181-184,共4页
West China Journal of Pharmaceutical Sciences
关键词
萘普生
芳基丙酸
合成
d-单甲基化
dl-Naproxen
Solid-liquid phase-transfer catalysis
α-Monomethylation
Synthesis
