摘要
通过讨论缩酮结构、离去基活性和芳基迁移活性对重排反应的影响,总结了经重排反应合成2-芳基丙酸的一些规律。
Some regularities in synthesis of 2 arylpropionic acid by the rearrangement reacticn have been summarized based on the effects of ketal structures, activation of leaving group and arylmigration on it. A good technique, that is asymmetric rearrangment synthesis of S Naproxen, is recommended.
关键词
芳基丙酸
重排反应
萘普生
消炎药
arylpropionic acid rearrangement reaction Naproxen