摘要
以3-苯甲酰基苯乙腈为原料,采用碳酸二甲酯进行α-甲基化反应制备2-(3苯甲酰基苯基)丙腈,使反应控制在单甲基化阶段,HPLC测定产物含量99.7%。同时探讨了催化剂的选择、反应温度、反应时间对反应的影响。
2-（3-Benzoylphenyl）propionitrile which was an important intermediate of ketoprofen was synthesized from 3-benzoylbenzeacetonitrile via monomethylation in the presence of dimethyl carbonate, Pure compound was obtained and the content of crystal was about 99.7%. The influence of catalysts, reaction temperature and reaction time on reactions were discussed.
出处
《精细化工中间体》
CAS
2007年第2期54-55,共2页
Fine Chemical Intermediates
基金
吉首大学人才引进资助项目(2005年)
吉首大学福特基金科技创新项目(07JDPHE056)。
