摘要
目的本实验在于分析乙酰胆碱-外侧隔(Ach-SL)升压系统与中央杏仁核(AC)情绪升压环路之间的关系。方法脑内核团微量注射不同的药物,记录血压和心率的变化。结果(1)促肾上腺素(CRF)或P物质(SP)注射入双侧SL可引起升压反应。L-谷氨酸钠(Glu)微量注射到AC的升压反应均被双侧SL内注入CRF或SP拮抗剂所减弱。(2)阿托品(Atro)预先注入双侧外侧僵核(HBL)、蓝斑(LC)、延髓头端腹外侧区(RVL),Glu对AC的升压反应可被减弱。(3)HBL有Ach能神经纤维投射到背侧丘脑后核(HP)并兴奋HP,HP又通过RVL、LC-RVL产生升压反应。Atro预先注入HP可减弱Glu对AC的升压反应。结论用Glu兴奋SL能依此有效地兴奋HBL、LC、RVL,此系统的各个通路由M-受体介导,SL-HBL(或HBL-HP)-LC-RVL的升压系统参与AC情绪升压环路。
Objective The present study was to analyze the role of ACh - lateral septum （SL） pressor system in the Central amygdaloid nucleus （AC） - emotional pressor circuit. Method Interurban microinjection of different drugs,then blood pressure and heart vate were vecorded. Results （ 1 ） CRF （ corticotropin releasing factor） or SP （ substance P） microinjection into the SL can induced pressor responses. The AC pressor responses to glutamate （Glu） could be attenuated by preinjection of CRF antagonist or SP antagonist into bilateral SL. （2） the AC pressor responses to Glu were also reduced by preinjection of atropine into either bilateral HBL , LC or RVL respectively, （3） Since lateral HB （HBL） projects to the posterior hypothalamus （HP） containing ACh -ergic neurons, and excitation of the latter produces pressor response via the RVL and LC -RVL; atropine preinjection into the HP could also decrease the HBL - and AC -pressor response. Conclusion The present results indicate that the AC produce pressor responses involved with the SL via their CRF and SP, mechanism underlying pressor response of SL is involved in pressor response of AC.
出处
《医学研究杂志》
2008年第3期38-42,共5页
Journal of Medical Research
基金
云南省教育厅科学研究基金项目(02ZY136)
关键词
乙酰胆碱
外侧隔
中央杏仁核
升压反应
情绪
压力
Acetylcholine
Lateral septum
Central amygdaloid nucleus
Pressor response
Emotion
Stress
