摘要
目的:为了验证ANP能神经是否从第三脑室前腹侧区(AV3V)投射到穹窿下器(SFO)。方法:用脑内微量注射药物,观察动脉血压和心率变化。结果:(1)心房钠尿肽(APeⅢ)注入SFO后,引起血压下降。(2)在SFO预注射A 71915(一种心房钠尿肽Ⅲ的抑制剂),产生谷氨酸兴奋AV3V的相反效应。结论:刺激AV3V的心房钠尿肽能神经,可在SFO引起降压效应。A71915注入SFO核团可反转AV3V的降压效应。
Objective： To prove whether or not the ANP ergic projections from the AV3V can act upon nuclei involved in subfornical organ. Method：The changes in arterial pressure and heart rate were observed after intrabrain microinjection of drugs. Results： （1） Atriopeptin Ⅲ-injection into SFO induced a depressor response. （2） Preinlection of A71915 （an atriopeptin Ⅲ antagonist） into SFO reversed the depressor response of the AV3V to glutamate. Conclusion： Excitation of atriopeptinergic neurons in the AV3V can produce an inhibitory effect on each nucleus in the SFO, and A71915 injection into SFO can reverse the AV3V depressor response.
出处
《医学理论与实践》
2007年第9期999-1001,共3页
The Journal of Medical Theory and Practice
基金
云南省教育厅科学研究基金项目(边缘前脑内血管紧张素II系统调节血压机制的实验研究02ZY136)
关键词
脑
第三脑室前腹侧区
穹窿下器
降压反应
Brain, Anteroventral third ventricle region, Subfornical organ, Depressor response
