摘要
乌拉坦麻醉、箭毒制动的大鼠在人工呼吸维持下，将谷氨酸钠（Ｇｌｕ）注入岛皮层引起血压升高、心率加快；而岛皮层周围区注入Ｇｌｕ或岛皮层内注入生理盐水对血压和心率无明显影响。双侧延髓头端腹外侧区（ＲＶＬ）内分别注入酚妥拉明、心得安或阿托品均可削弱兴奋岛皮层引起的升压反应，ｉ．ｖ．酚妥拉明也有这削弱的效应，但ｉ．ｖ．心得安或甲基阿托品则无明显作用。上述结果表明岛皮层引起的升压反应是由ＲＶＬ（α－，β－和Ｍ－受体）－交感缩血管神经系统介导的。
In urethane-anesthetized,in boon r ar in e--im mobilized an d a rtificially ye n tilated rats,microinjection of L--glutamate(Gin)ipto the insular cortex(INS)caused a rise in blood pressure and heart rate. Bilateral injection of either phentolamine,propranolol or atropine into the rostral ventrolateral medulla(RVL)all could decrease the INS-pressor response.The latter could also be attenuated by phentolamine(i.v.),but not by propranolol or methyl atropine.These results indicate that the INS-pressor response is mediated by RVL(a-,& and M-receptors)-sympathetic vasoconstrictor nerve system.
出处
《生理学报》
CAS
CSCD
北大核心
1994年第6期591-596,共6页
Acta Physiologica Sinica
基金
卫生部科研基金
国家自然科学基金
关键词
升压反应
岛皮层
延髓
交感神经系统
高血压
pressor response
insular cortex
rostral ventrolateral medulla
phentolamine
propranolol
atropine
