摘要
全身或局部的病变可导致血—视网膜屏障破坏、血液微循环障碍和血管通透性改变,进一步引起视网膜缺氧,乃至水肿,随之视网膜组织对缺氧发生一系列代偿性反应,在各种细胞因子、细胞内外调控机制的共同作用下生成新生血管,目的是补偿缺血缺氧的视网膜。视网膜新生血管相关疾病包括糖尿病性视网膜病变、视网膜静脉周围炎、早产儿视网膜病变等。抑制新生血管生长是治疗这类疾病的关键。本文对抑制视网膜新生血管药物的研究进展作一综述。
The systemic or partial body diseases may cause the damage to the blood-retinal barrier, blood microcirculation and vessel permeability. Furthermore,they lead to retinal anoxia and edema. Then retinal tissue has a series of compensatory response to the anoxia and neovascularization, which aims to nourish the retina that is deficient in blood and oxygen. The diseases related to retinal neovascularization include diabetic retinopathy, retinal periphlebitis, retinopathy of prematurity, etc. The key to treating these diseases is to inhibit the development of the neovascularization. This paper reviewed the progress in medicine therapy for inhibiting retinal neovascularization.
出处
《国际眼科杂志》
CAS
2008年第2期358-360,共3页
International Eye Science
关键词
视网膜新生血管
药物
治疗
retinal neovascularization
medicine
treat-ment
