摘要
目的观察不同类型冠心病患者血中氧化低密度脂蛋白(ox-LDL)、凝集素样氧化低密度脂蛋白受体-1(LOX-1)水平的变化及其之间的关系,探讨临床预测急性冠脉综合征(ACS)的血清学指标。方法采用酶联免疫吸附法测定40例冠心病患者[ACS20例、稳定型心绞痛(SAP)20例]、20例非冠心病患者血清ox-LDL、LOX-1的变化。结果ACS患者外周血清总胆固醇(TC)、低密度脂蛋白(LDL)、ox-LDL、LOX-1水平均高于SAP和非冠心病患者;SAP患者外周血清ox-LDL、LOX-1高于非冠心病患者。ACS患者治疗后ox-LDL、LOX-1水平均低于治疗前。ACS患者LOX-1与ox-LDL呈正相关(P<0.01)。结论ACS患者外周血清ox-LDL、LOX-1水平升高,二者可作为动脉粥样硬化斑块不稳定的血清学指标。
Objective To investigate the serum levels of oxidized low density lipoprotein（ ox- LDL）, lectin - like oxidized low - density lipoprotein receptor - 1 （ LOX - 1 ） in coronary artery disease of different types and their correlation, and to explore the pathogenesls of acute coronary syndrome （ACS）. Methods Enzyme - linked immunosorbent assay was used to measure the ox - LDL, LOX - 1 levels in 40 patients with coronary artery disease （20 with ACS and 20 with stable angina pectoris ） and 20 controis. Results In the patients with ACS, serum TC, LDL, ox -LDL, LOX - 1 levels were significantly higher than those in control group and stable angina pectoris group. In patients with stable angina pecto- ris, ox - LDL and LOX - 1 levels were significantly higher than those in control group. The serum levels of LOX - 1, ox - LDL in the patients with ACS decreased significantly after therapy. Significantly positive correlation between the serum levels of LOX - 1 and ox - LDL was observed in the patients with coronary artery disease. Conclusion Serum ox - LDL, LOX - 1 levels were elevated in ACS patients, which shows the possible relation to the pathogenesis of ACS and may serve as a potential marker of plaque instability.
出处
《中国急救医学》
CAS
CSCD
北大核心
2007年第12期1070-1072,共3页
Chinese Journal of Critical Care Medicine
关键词
氧化低密度脂蛋白
凝集素样氧化低密度脂蛋白受体-1
急性冠脉综合征
Oxidized low density lipoprotein （ ox - LDL）
Lectin - like oxidized lowdensity lipoprotein receptor - 1 （ LOX - 1 ）
Acute coronary syndrome （ACS）
