摘要
组胺是各种炎症反应中重要的介质,许多物质都具有导致人体和大鼠肥大细胞释放组胺的不良反应。虽然肽类药物相对于其他药物而言,具有活性高,不良反应小等优点,但一些活性肽类化合物也能引起组胺释放,使得这些肽类药物临床使用受到限制。对肽类物质的组胺释放作用研究,有助于进一步改善肽类药物的某些不良反应,降低其毒性。现列举了部分内源性和外源性的肽类物质,并对其组胺释放作用机制进行了综述。
Histamine is an compounds have been known to ind important mediator induce histamine release various kinds of inflammato peptide drugs have higher bio-activity and lower side-effect th peptides also induce histamine release, and clinical develop human and rat mast c an other kinds of drugs. ment of them have been ry reactions. Many ells. As we know, But some bioactive also restricted because of side effects of histamine release. Some endogenous and exogenous peptides with histamine-releasing potency and related mechanism were summarized in this paper.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2007年第22期1834-1838,共5页
Chinese Journal of New Drugs
基金
国家自然基金(30500629)
北京科委基金(Z0005187040531)
关键词
组胺释放
多肽
肥大细胞
histamine release
peptides
mast cell
