摘要
目的:考察薄荷醇的止痒作用,并探讨其止痒作用的机制。方法:联合应用组胺和4-氨基吡啶(4-AP)建立瘙痒模型,考察薄荷醇的止痒作用;采用豚鼠离体回肠实验观察组胺诱导回肠平滑肌收缩张力的变化以及薄荷醇的作用;采用豚鼠腹腔肥大细胞组胺释放体外法观察薄荷醇的抑制作用。结果:薄荷醇高、中、低剂量组30min内在搔抓次数与空白模型组相比显著减少,高剂量组搔抓潜伏期与空白模型组相比显著延长;薄荷醇高剂量组能明显抑制组胺引起的回肠平滑肌张力收缩;薄荷醇高剂量组能抑制豚鼠腹腔细胞组胺释放作用。结论:薄荷醇具明显的止痒作用,其止痒作用与对抗组胺的作用和抑制组胺释放有关。
Objective： To investigate the antipruritie effect of menthol and its related mechanism. Methods ： Pruritus model was made by using the histamine and 4-aminopyridine（4-AP） ,and the antipruritie effect of menthol was observed; The changes of ileum smooth muscle tension induced by histamine and the effect of menthol were observed in the isolated guinea pig ileum experiment ;The effect of menthol inhibiting histamine relasased by Guinea pig peritoneal mast cells was studied in vitro. Results ：The frequency of scratching within 30 minutes of the menthol group（ high ,middle and low dose） was significantly less than that of the blank group and the latent time of the high-dose group was significantly longer than that of the blank group. The ileum smooth muscle contraction induced by histamine was significantly inhibited by the menthol high -dose group;menthol high -dose group ,The release of histamine from Guinea pig peritoneal mast cells was significantly inhibited by menthol high-dose group. Conclusion：Menthol has satisfactory anfipmritic effect, and its mechanism might relate to antihistamine effect and release of histamine.
出处
《中华中医药学刊》
CAS
2009年第7期1488-1490,共3页
Chinese Archives of Traditional Chinese Medicine
基金
广东省科技计划资助项目(2007A060305006)
