摘要
目的探讨脑多巴胺转运体显像剂99Tcm-TRODAT-1在基底神经节的分布特点,以及单光子发射型计算机断层显像(SPECT)对诊断帕金森病(PD)的价值。方法将35例PD患者(PD组)和16例健康体检者(对照组)进行99Tcm-TRODAT-1 SPECT脑显像检查。以半定量方法分析,应用计算机感兴趣区(ROI)技术计算双侧横断位、矢状位纹状体(ST)/小脑(CB)放射性摄取率之比。结果对照组横断位左右侧和矢状位左、右侧ST/CB分别为(1.55±0.15)、(1.58±0.14)和(1.62±0.17)、(1.69±0.16)。PD组ST/CB比对照组明显减低,差异有显著性意义(P<0.01)。结论99Tcm-TRODAT-1在SPECT中显像是诊断PD的有效方法。
Objective To investigate the characteristics of distribution of ^99Tc^m-TRODAT-1 in the basal ganglia and evaluate the value of SPECT imaging in diagnosis of Parkinson＇s disease （PD）. Methods ^99Tc^m-TRODAT-1 SPECT imaging was used in 35 PD patients and sixteen age-matched healthy volunteers. The regions of interest were drawn manually on cerebellum （CB） ,three transverse,and sagittal plane slice-views of striatums（ST）. The uptake ratios of ST/CB were calculated using semiquantitative analysis. Results The ST/CB ratios of left and right transverse planes and sagittal planes in healthy volunteers were 1.55±0.15,1.58±0.14,1.62±0.17 and 1.69±0. 16 respectively. A lower specific uptake of ^99Tc^m-TRODAT-1 in striatums was displayed in 35 PD patients by visual inspection,compared with healthy volunteers. The uptake ratios ST/CB in the basal ganglia of PD were significantly lower than those of healthy volunteers （ P 〈0.01 ）. Conclusion ^99Tc^m-TRODAT-1 SPECT imaging is an effective method for diagnosis of PD.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2007年第9期608-610,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
广东省卫生厅医学科学技术研究基金资助(A2001515)
