摘要
目的 研究长期大剂量使用复方磷酸可待因口服液产生依赖对脑纹状体功能的损害.方法 29例复方磷酸可待因口服液依赖者、27例海洛因依赖者和31例健康志愿者分别行99Tcm-2β-[N,N＇-双（2-巯乙基）乙撑二胺基]甲基,3β-（4-氯苯基）托烷（TRODAT-1）SPECT显像,定性分析多巴胺转运蛋白（DAT）影像特征,同时定量分析3组受试者纹状体体积（V,cm3）、质量（m,g）和纹状体与全脑放射性比值（Ra,%）.使用SPSS 13.0软件对3组受试者的V、m和Ra进行t检验.结果 健康对照组双侧纹状体呈典型＂熊猫眼＂形态,DAT放射性分布均匀、对称;复方磷酸可待因口服液依赖者双侧纹状体外形变小,形态失常,放射性分布减低、缺损甚至紊乱,存在部分非特异性放射性分布;海洛因依赖者与其类似.复方磷酸可待因口服液依赖组双侧纹状体V=（23.68±4.94）cm3、m=（24.87±5.19）g、Ra=（5.01±0.88）%,均低于健康对照组的（35.39±4.42）cm3、（37.16±4.64）g和（7.93±0.86）%,t=-9.69,-9.69,-13.01,P均=0.000,高于海洛因依赖组的（18.87±4.66）cm3、（19.81±4.90）g和（4.26±1.02）%,t=3.74,3.74,2.96,P分别为0.000,0.000,0.005.结论 长期大剂量使用复方磷酸可待因口服液产生依赖可破坏纹状体功能,使纹状体部位DAT的分布、密度和活性减低,类似海洛因成瘾性脑病.
Objective To study the damage to striatum in patients perorally addicted to compound codeine phosphate solution by using the brain dopamine transporter SPECT imaging. Methods Patients p erorally addicted to compound codeine phosphate solution （ n = 29 ） and addicted to heroin （ n = 27 ）, as well as healthy volunteers （n = 31 ） were included in the study. Each of them underwent dopamine transporter （DAT） SPECT imaging with 99Tcm-2β-[N, N＇-bis-（ 2- mercaptoethyl ） ethylenediamino] methyl, 3β-（4-chlorophenyl）tropane （99Tcm-TRODAT-1）. The striatum volume （V, cm3）, mass （m, g） and radiactivity ratio （Ra） of striatum to whole brain were calculated using physio-mathematical modeling method.R esults Bilateral striatum of healthy volunteers showed typical ＂panda eyes＂ pattern and the distribution of DAT was uniform and symmetrical. Bilateral striatum of patients addicted to compound codeine phosphate showed impaired tracer uptake, similar to those addicted to heroin. The V, m and Ra of bilateral striatum of patients addicted to compound codeine phosphate were （23.68 ±4.94） cm3, （24.87 ±5.19） g and （5.01 ±0. 88 ） %, respectively, which were significantly lower than those of healthy controls： （ 35.39 ± 4.42 ） cm3,（37.16 ±4.64） g and （7.93 ±0.86）% （t = -9.69, -9.69, - 13.01, all P =0.000）, but significantly higher than those addicted to heroin： （ 18.87 ± 4.66 ） cm3, （ 19.81 ± 4.90 ） g and （4.26 ± 1.02 ） % （ t =3.74, 3.74, 2.96, P = 0.000, 0.000, 0.005 ）. Conclusion Long-term peroral intake of compound codeine phosphate solution may damage the function of cerebral striatum, which is someway similar to though less severe than, the impairment caused by heroin.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2010年第6期379-382,共4页
Chinese Journal of Nuclear Medicine
基金
广东省教育部产学研结合项目（2008B090500129）
