摘要
目的研究肺癌组织中细胞间粘附分子-1的表达及其临床意义。方法应用流式细胞仪检测技术检测了60例人肺癌组织中细胞间粘附分子-1的表达,并与正常肺组织中细胞间粘附分子-1的表达比较,进一步探讨肺癌细胞产生的1型细胞间粘附分子在肺癌侵袭和转移过程中的作用。结果60例肺癌组织中有54例ICAM-1表达明显增强,其含量明显高于正常组织(P<0.01),Ⅲ-Ⅳ期肺癌组织中ICAM-1的表达明显高于Ⅰ-Ⅱ期组。结论ICAM-1与肺癌的侵袭和转移有关,有可能作为预测肺癌转移、复发及预后的指标。
Objective To investgate the expression of intercellular adhesion molecule-1（ICAM-1） and its Clinical significance in lung cancer.Methods Sixty cases of lung cancer samples were determined by flow cytometer to investigate the expression of ICAM-1 and compared that with healthy lung tissues.Further researching the function of ICAM-1 in the invasion and metastasis of lung cancer. Lung cancer samples were in paraffin-embeded.It include clinical stage Ⅰ-Ⅱ 30 samples,stage Ⅲ-Ⅳ30 samples.Results Sixty cases expressed higher level of ICAM-1 than that in healthy lung tissues（P〈0.01）.The expression of of ICAM-1 has significant difference between normal tissue and lung cancer,but no statistically significant difference was found between clinical stage Ⅰ-Ⅱ and clinical stage Ⅲ-Ⅳ（P〉0.05）.Conclusions ICAM-1 as a suppressor,may play an important role in carcinogenesis,and progression.It may be useful in lung cancer＇s predict,diagnosis and prognosis of lung cancer.
出处
《医学信息（手术学分册）》
2007年第6期531-532,共2页
Medical Information Operations Sciences Fascicule
