摘要
目的:研究急性白血病患者血清白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)和可溶性细胞间黏附分子-1(sICAM-1)水平及其临床意义。方法:选取2017-04-2019-04我院收治的急性白血病患者127例为样本进行前瞻性研究,入院后采集患者资料,完善相关检查并给予化疗,观察疗效并随访预后,根据结果对患者进行分组并比较血清sICAM-1、IL-10和TNF-α水平差异,作受试者工作特征曲线并计算曲线下面积(AUC)分析各指标对急性白血病分型及疗效和预后评估的临床价值。结果:急性白血病患者血清sICAM-1、IL-10和TNF-α水平均明显高于对照组(P<0.05);急性淋巴细胞白血病组血清IL-10水平高于急性髓系白血病组,血清TNF-α水平低于急性髓系白血病组,差异均有统计学意义(P<0.05);完全缓解组血清IL-10水平低于非完全缓解组,血清TNF-α水平高于非完全缓解组,差异均有统计学意义(P<0.05);死亡组血清sICAM-1和IL-10水平均高于存活组,血清TNF-α水平低于存活组,差异有统计学意义(P<0.05);血清IL-10和TNF-α水平对急性白血病分型的AUC分别为0.720和0.865,评估急性白血病疗效的AUC分别为0.792和0.754,血清sICAM-1、IL-10和TNF-α水平用于急性白血病预后判断的AUC分别为0.717、0.750和0.840。结论:急性白血病患者血清sICAM-1、IL-10和TNF-α水平存在明显异常,对病变分型诊断及疗效和预后评估均具有良好参考价值。
Objective:To study the levels and clinical significance of serum interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),and soluble intercellular adhesion molecule-1(sICAM-1) in patients with acute leukemia(AL).Method:A total of 127 patients with AL admitted to our hospital from April 2017 to April 2019 were selected for prospective study.After admission,the data of patients were collected. Relevant examinations were conducted and chemotherapy was given.The efficacy was observed and the prognosis was followed up.The patients were grouped according to the results,and the levels of serum sICAM-1,IL-10,and TNF-α were compared.The receiver operating characteristic curve was drawn and the area under the curve(AUC) was calculated to analyze the clinical value of various indicators in the evaluation of AL classification and efficacy and prognosis.Result:The levels of serum sICAM-1,IL-10,and TNF-α in patients with AL were significantly higher than those in healthy control group(P<0.05).The serum IL-10 level in the ALL group was higher than that in the AML group while the serum TNF-α level was lower than that in the AML group(P<0.05).The serum IL-10 level of the CR group was lower than that of the non-CR group while the serum TNF-α level was higher than that of the non-CR group(P<0.05).The levels of serum sICAM-1 and IL-10 in the death group were higher than those in the survival group while the level of serum TNF-α was lower than that in the survival group(P<0.05).The AUC values of levels of serum IL-10 and TNF-α on AL classification were 0.720 and 0.865 respectively,and the AUC values of evaluating the efficacy of AL were 0.792 and 0.754,and the AUC values of serum sICAM-1,IL-10 and TNF-α levels in determining the prognosis of AL were 0.717,0.750 and 0.840 respectively.Conclusion:The serum levels of sICAM-1,IL-10,and TNF-α in AL patients are obviously abnormal,and they have a good reference value for the diagnosis of pathological classification and evaluation of efficacy and prognosis of AL patients.
作者
陆小云
张焕新
LU Xiaoyun;ZHANG Huanxin(Department of Hematology,Heze Hospital of Chinese Traditional Medicine,Heze,274000,China;Department of Hematology,Xuzhou Medical University)
出处
《临床血液学杂志》
CAS
2020年第6期762-766,共5页
Journal of Clinical Hematology
