摘要
目的:研究碳酸钙和生物碳酸钙经口给药后对摘除卵巢大鼠骨质疏松症模型的影响。方法:用摘除卵巢法建立大鼠骨质疏松模型,碳酸钙和生物碳酸钙连续经口给药12周,以子宫系数、血清雌二醇、骨碱性磷酸酶、骨灰重系数、骨钙含量、骨矿密度、骨生物力学为观察指标。结果:碳酸钙和生物碳酸钙均可明显增加股骨的灰重系数和骨钙含量,提高模型大鼠的股骨最大载荷、挠度和能量吸收,改善骨生物力学性能。生物碳酸钙可显著增加股骨远心端骨密度。结论:碳酸钙和生物碳酸钙均可明显改善去卵巢大鼠的骨生物力学性能,能防治去卵巢诱导的大鼠骨质疏松症,生物碳酸钙的作用略优于碳酸钙。
Objective： To study the effects of biological calcium carbonate（B-CaCO3） and calcium （CaCO3） on osteoperosis in ovariectomized mrs. Methods： The rat model of osteoperosis was induced by ovariectomy. Having been fed with B-CaCO3 and CaCO3 for 12 weeks, the concentration of alkaline phosphatase in bone （b-ALP） was measured by colorimetric method. The concentration of estradiol（E2） in serum was measured by competitive radio immunologic method. Bone mineral density（BMD） of femur of rats was determined by Dual Energy X-ray Absorptiometry （DEXA）. Biomechanical characteristics of femur were measured by three point bending test. Results： The BMD of femur of rats and femur weight were increased. The resistance of bending and compression of femur of rats was enhanced, and B-CaCO3 can increase the BMD of distal femur remarkably. Conclusion： Both B-CaCO3 and CaCO3 had antiostcopomtic effects on ovariectomized rats, and B-CaCO3 has much mere effect on osteoperosis than CaCO3.
出处
《药学进展》
CAS
2007年第2期74-78,共5页
Progress in Pharmaceutical Sciences
关键词
碳酸钙
去卵巢大鼠
骨质疏松
骨生物力学
Calcium carbonate
Ovariectomized rats
Osteoporosis
Bone biomechanics
