摘要
目的 研究糖皮质激素诱导大鼠骨质疏松模型及依扑拉芬对糖皮质激素引起大鼠骨质疏松的防治作用。方法 ｉｍ 氢化泼尼松４－５ ｍｇ·ｋｇ－１ ，每周２ 次，共８ ｗｋ 可引起大鼠体重明显降低，血清有机磷含量和碱性磷酸酶活性升高，尿钙浓度和２４ ｈ 尿钙排泄量增加以及骨灰重降低，引起大鼠骨密度降低导致骨质疏松。结果 氢化泼尼松（４－５ ｍｇ·ｋｇ－ １ ，ｉｍ ，每周２ 次，共８ ｗｋ） 可诱导大鼠骨质疏松模型，而依扑拉芬（１００、２００ 与４００ ｍｇ·ｋｇ－１）对糖皮质激素引起的大鼠体重降低，血清ｐｉ 含量及碱性磷酸酶活性升高，尿钙排泄量增加和骨灰含量以及骨密度降低均有拮抗作用。
AIM Effect of ipriflovone on glucocorticoid induced ostesporosis was studied in rats. METHODS Ostesporosis of the rats was induced by prednisolone(Pred, im, 4 5 mg·kg -1 ,twice a week, for 8 weeks). RESULT Ipriflavone significantly Prevented the decreasing weight of rat, increasing serum content of inorganic phosphorus and AKP activity, and overexcreting of calciuia caused by Pred. It also recoved and increased the fractional content of ash and the density of femure. CONCLUSION Ipriflavone can significantly provent the dstesporosin of rats caused by Pred.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1999年第5期474-476,共3页
Chinese Pharmacological Bulletin
